Medical Questions

Which tests are recommended to identify active substances and drug(s) that work against the disease?
Onconomics or Onconomics Plus
Which is the most comprehensive test?
ONCOSTAT PLUS, which covers the sensitivity/resistance on conventional & biological/natural substances and CHEMOSNIP which covers the ability of the patients to activate the drugs and metabolize them properly.
Which tests are recommended for follow up and patient monitoring?
Oncocount Neeligenetics. or Oncotrace Neeligenetics. or Oncotrail Neeligenetics only for known and specific types of malignancies.
Which is the time interval for follow-up support tools?
For the first year every trimester and then every half year
Which test focuses on the status of the immune system and immunity?
Which test focuses on the efficacy of therapeutic agents against a cancer of an individual patient?
Can a patient include additional substances to any of your tests?
If a patient asks for additional natural substances to be tested, we can include them in Onconomics Plus or Onconomics Extracts. If additional testing for chemotherapy drugs is required, we are able to include them in the Onconomics test.
What techniques were used to overcome the known difficulties of successfully culturing chondrosarcoma cells from a blood test given that the tumor has not metastasized??
The migration from the primary tumor take place relatively early during tumor progression. Almost less than 2mm in diameter the primary tumor already spreads newly form vessels and cells that perform EMT are migrate through them to the circulation.
In the case of 62 males with enlargement of prostate with no possibility of a biopsy, what would be the tools for diagnosis, guidance and possible follow up? What are the crucial markers?
Oncotrace Neeligenetics for diagnostic guide and Prostate oncotrail Neeligenetics for follow up focused in PSMA and PSA markers.
Is it possible to determine through blood testing if a person is resistant or sensitive to a specific chemotherapeutic agent based on blood?
The isolation of CTCs can be performed with sorting methods based on Flow cytometry and avoid any noise caused by irrelevant cells. The evaluation of CTCs can reveal sensitivity and resistance to several factors in a cellular level. The application to an all organism requires the cooperation and expertise of an oncologist which have very high level of knowledge of pharmacology (Pharmacodynamics and pharmacokinetic) in order to schedule dosages, timing and cycles in a patient level.
We use specialized formulations and products not listed for your lab. Am I able to send samples for testing? Are these also tested in combination, as many patients take more than one thing at a time?
Besides the cytotoxic drugs, the monoclonal antibodies or the small molecular weight inhibitors like TKIs, we can test other substances either by a viability/cytotoxicity assay and as induction of the immune response or as inhibitors of growth factor receptors. You can introduce to us any substance you deem fit If you prefer to test these in combination we can offer also that, but it is up to the physician to specify the combination, the timing of each component and the ratio.
Which test is appropriate for gene expression?
The onconomics and onconomics plus test study the expression of specific genes correlated with the efficacy of specific drugs on the cancer cells derived from a single patient.
Does ChemoSNiP examine the cause of mutation?
ChemoSNiP provides information about DNA sequence variations (mutations) that can affect how humans develop disease or respond to chemicals, drugs and other agents.
Even if the test requires both blood and tissue, we can provide only blood and the test could be done?
Every RGCC test can be conducted with blood sample. Only the type of cancer can change this fact. For example, to examine glioblastoma and other types of brain cancer, only tissue is necessary in order to proceed to RGCC tests.
Since many patients do not have a tissue (inoperable or the surgery was long time ago) is it still possible to make those tests (onconomics PLUS)?"
Yes, patients can have RGCC tests with blood sample, except from the cases of brain cancer/tumor.
Is it possible to be found the origin of the primary tumor?
The CGH test provide information about genetic abnormalities (deletions/insertions) on the tumor cells. These abnormalities can be associated with of the primary tumor. This test is quite new. Because of that, it is not yet in our website.
Could the patients with lymphoma or leukemia examine their CTC count?

We have many patients with lymphoma or leukemia who have proceeded to RGCC test for CTC count.